Work Package 2: Epigenetics
Rationale: Epigenetics can be defined as stable alterations in gene expression potential that arise during development and cell proliferation [1]. These alterations are associated to biochemical modifications of the DNA and chromatin and can be affected by environmental stimuli [2] including the maternal diet effects [3]. DNA methylation and histone modifications are the well-studied epigenetic modifications.
Objectives of WP2 at start of SABRE
- New knowledge on the contribution of epigenetics to the variability of phenotypic traits
- Develop a sensitive readout of the epigenetic status of the genome of domestic species for the combined use of molecular genetic testing and epigenetic analysis in selection
- Provide new input on the genetic to environmental effects for a better control and even manipulation of the ways in which the genome “learns by experience”.
WP Leader: Dr Jean Paul Renard (Institute National de la Recherche Agronomique)
Partners involved:
- Institute National de la Recherche Agronomique
- Research Institute for the Biology of Farm Animals, FBN-Dummerstorf
- Institute for Animal Genetics, Nutrition and Housing, University of Berne
- University of Munich
References
[1] Jaenisch, R and Bird, A. Nat. Gen. 33, 245-254 (2003)
[2] Mays-Hoppes, L. et al. Dev. Genet. 7, 65-73 (1986)
[3] Wolff, G.F. et al. Faseb J. 12, 949-957 (1998)